If you disconnect the cables from those two connectors (be sure to tuck them out of the way and/or cover with electrical tape so they can't contact the motherboard, case, or other components), you could physically disable both front USB ports.īUT, BUT. The manual shows two connectors on the motherboard for the front USB ports. You'll also need a password protected Admin account and only that account has the right to modify the registry or re-run IntelliAdmin to re-enable USB access. Note: if you use them, only encrypted USB drives and encrypted USB sticks are HIPAA compliant. The problem with software approaches, either editing the registry or using an app like IntelliAdmin, is they disable all USB storage devices for all users. So you won't be able to connect a USB drive or USB stick either.